Application

CGP77675 has been used in the generation of mouse expanded potential stem cells.

Biochem/physiol Actions

CGP77675 prevents hypercalcemia stimulated by interleukin 1β. It is known to offer protection against bone loss in ovariectomized mice. CGP77675 is known for its use in cancer treatment.

CGP77675 is a potent Src kinase inhibitor. CGP77675 is selective toward other protein kinases including Cdc2 (>500-fold), epidermal growth factor (EGF) receptor (7.5-fold), vascular endothelial growth factor receptor (>50-fold), and for v-Abl (15-fold) and focal adhesion kinase (Fak) (>25-fold).

Features and Benefits

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General description

CGP77675 belongs to the pyrrolopyrimidine class of inhibitors.

Packaging

5, 25 mg in glass bottle