SR 48692, >=98% (HPLC)

Code: SML0278-5MG D2-231

Application

SR 48692 has been used as a neurotensinhigh-affinity receptor 1 (NTSR1) antagonist: to explore the function of NTSR1 in glioblastoma (GBM) cells to determine the ...


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€126.30 5MG
€155.35 inc. VAT
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Application

SR 48692 has been used as a neurotensinhigh-affinity receptor 1 (NTSR1) antagonist: to explore the function of NTSR1 in glioblastoma (GBM) cells to determine the roles of neurotensin (NT) in the regulation of bile acid(BA) uptake, in vivo to explore the involvement of NTSR1 versus NTSR2 in mice

Biochem/physiol Actions

SR 48692 is a high affinity, orally bioavailable and selective nonpeptide NT1 neurotensin receptor antagonist that antagonizes neurotensin-induced calcium mobilization with a pA2 of 8.13 in HT-29 human colon carcinoma cell line, and blocks the ability of neurotensin to increase GABA levels in the prefrontal cortex.

Features and Benefits

This compound is featured on the Neurotensin Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Packaging

5, 25 mg in glass bottle

assay≥98% (HPLC)
colorwhite to beige
formpowder
Gene Informationhuman ... NTSR1(4923)
InChI keyDYLJVOXRWLXDIG-UHFFFAOYSA-N
InChI1S/C32H31ClN4O5/c1-41-27-4-3-5-28(42-2)29(27)26-16-24(36-37(26)25-8-9-34-23-15-21(33)6-7-22(23)25)30(38)35-32(31(39)40)19-11-17-10-18(13-19)14-20(32)12-17/h3-9,15-20H,10-14H2,1-2H3,(H,35,38)(H,39,40)
Quality Level100
SMILES stringCOc1cccc(OC)c1-c2cc(nn2-c3ccnc4cc(Cl)ccc34)C(=O)NC5(C6CC7CC(C6)CC5C7)C(O)=O
solubilityDMSO: ≥2 mg/mL (warmed)
storage temp.−20°C
Cas Number146362-70-1
This product has met the following criteria to qualify for the following awards:



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