Thiamet G, >=98% (HPLC)

Code: SML0244-25MG D2-231

Application

Thiamet G has been used as an O-GlcNAcase inhibitor:to treat human embryonic kidney 293 cells in order to study its effect on Wnt/beta-catenin signalling...


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€503.20 25MG
€618.94 inc. VAT
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Application

Thiamet G has been used as an O-GlcNAcase inhibitor:to treat human embryonic kidney 293 cells in order to study its effect on Wnt/beta-catenin signallingto treat lytically-replicating producerto incubate mice (C57BL/6) aortic segments to increase global O-GlcNAc levels

Biochem/physiol Actions

Thiamet G is a potent inhibitor of the enzyme O-GlcNAcase (Ki = 21 nM). The compound is orally bioavailable and crosses the blood brain barrier. Thiamet G leads to an increase in O-GlcNAc-modified proteins in cell-based and in vivo assay systems, and reduces levels of phosphorylated Tau protein in rat cortex and hippocampus.

Packaging

5, 25 mg in glass bottle

assay≥98% (HPLC)
colorwhite to beige
formpowder
InChI keyPPAIMZHKIXDJRN-FMDGEEDCSA-N
InChI1S/C9H16N2O4S/c1-2-10-9-11-5-7(14)6(13)4(3-12)15-8(5)16-9/h4-8,12-14H,2-3H2,1H3,(H,10,11)/t4-,5-,6-,7-,8-/m1/s1
optical activity[α]/D -21 to -26°, c = 0.3 in methanol
Quality Level100
SMILES stringCCNC1=N[C@@H]2[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]2S1
solubilityH2O: ≥5 mg/mL at warmed to 60 °C
storage conditiondesiccated
storage temp.−20°C
Cas Number1009816-48-1
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