IM-12, >=98% (HPLC)

Code: SML0084-5MG D2-231

Biochem/physiol Actions

IM-12 is a cell-permeable indolylmaleimide that acts as a Glycogen synthase kinase 3β (GSK-3β) inhibitor, activating downstream components o...


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€143.90 5MG
€177.00 inc. VAT
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Biochem/physiol Actions

IM-12 is a cell-permeable indolylmaleimide that acts as a Glycogen synthase kinase 3β (GSK-3β) inhibitor, activating downstream components of canonical Wnt signaling. IM-12 significantly increased β-catenin levels. When used to treat human neural progenitor cells, IM-12 promoted neuronal differentiation resulting in an increase of neuronal cells. It has an IC50 of 53 nM in an in vitro binding assay, compared with 92 nM for SB-216763 in the same assay condition.

Packaging

5, 25 mg in glass bottle

assay≥98% (HPLC)
coloryellow-orange
formpowder
InChI keyZKJAZFUFPPSFCO-UHFFFAOYSA-N
InChI1S/C22H20FN3O2/c1-13-18(16-5-3-4-6-17(16)25-13)19-20(22(28)26(2)21(19)27)24-12-11-14-7-9-15(23)10-8-14/h3-10,24-25H,11-12H2,1-2H3
Quality Level100
SMILES stringCN1C(=O)C(NCCc2ccc(F)cc2)=C(C1=O)c3c(C)[nH]c4ccccc34
solubilityDMSO: ≥9 mg/mL
storage conditiondesiccated
storage temp.2-8°C
Cas Number1129669-05-1
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