Application

SIB 1893 may be used in mGluR5 metabotropic glutamate receptor-mediated cell signaling studies.

Biochem/physiol Actions

Selective and noncompetitive mGlu₅ metabotropic glutamate receptor antagonist.

SIB 1893 non-competitively inhibits glutamate-induced increase in Ca²⁺ at human metabotropic glutamate receptor 1 (hmGluR1).¹ It also acts as a positive allosteric modulator of hmGluR4.²

Features and Benefits

This compound is featured on the Glutamate Receptors (G Protein Family) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Packaging

10 mg in ampule