(+/-)-Sulpiride,

Code: S8010-100G D2-231

Application

(±)-Sulpiride was used to study the effect of dopamine D2 receptor signaling on calcium channels in rat pituitary melanotropic cells.47...


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Application

(±)-Sulpiride was used to study the effect of dopamine D2 receptor signaling on calcium channels in rat pituitary melanotropic cells.47

Biochem/physiol Actions

(±)-Sulpiride is a D2 dopamine antagonist and an effective treatment for schizophrenia when used in combination with clozapine, a relatively weak D2-dopaminergic antagonist. It is an antipsychotic agent and also exhibits neuroleptic properties but poorly penetrates the central nervous system.45,46

Features and Benefits

This compound was developed by Sanofi Aventis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Reconstitution

Solutions may be stored for several days at 4 °C.

colorwhite
formpowder
Gene Informationhuman ... CA1(759), CA2(760), CA4(762), CA5A(763), CA5B(11238), CA9(768), DRD2(1813)
InChI keyBGRJTUBHPOOWDU-UHFFFAOYSA-N
InChI1S/C15H23N3O4S/c1-3-18-8-4-5-11(18)10-17-15(19)13-9-12(23(16,20)21)6-7-14(13)22-2/h6-7,9,11H,3-5,8,10H2,1-2H3,(H,17,19)(H2,16,20,21)
originatorSanofi Aventis
Quality Level100
SMILES stringCCN1CCCC1CNC(=O)c2cc(ccc2OC)S(N)(=O)=O
solubilityethanol: soluble, H2O: slightly soluble, 0.1 M HCl: soluble, 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 8.0 mg/mL
storage temp.2-8°C
Cas Number15676-16-1
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