Scriptaid, >=95%, solid

Application

Scriptaid has been used in post activation of oocytes and embryo culture.

Scriptaid was used to enhance transcriptional activity in cloning procedures by somatic cell nuclear transfer.^5,6

Biochem/physiol Actions

Histone deacetylase inhibitor with lower toxicity than trichostatin A; used to enhance protein expression.

Scriptaid inhibits the cell cycle progression of ovarian cancer cells by inducing arrest in G0/G1 and/or G2/M phase. Treatment of cells with scriptaid results in loss of mitochondrial membrane potential and increased acetylation of H3 and H4 histone tails.² Sciptaid induces expression of γ-globin in human erythroid progenitors via p38 signaling and may be a treatment option for sickle cell disease.³ It enhances the transcriptional activity and protein expression in mouse embryos. This is useful in producing cloned, inbred mouse embryos that develop normally into adulthood with regular reproductive ability.⁴

Features and Benefits

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General description

Scriptaid is a histone deacetylase (HDAC) inhibitor, which enhances global acetylation of histones. It improves transcriptional activity and protein expression. Scriptaid inhibits tumor growth. It decreases telomerase activity and stimulates glioma cell apoptosis.

Legal Information

Sold under license of U.S. Patent No. 6,544,957.

Packaging

5 mg in glass bottle

1 mg in poly bottle