SP600125, >=98% (HPLC)

Code: S5567-10MG D2-231

Application

C2C12 myoblasts were treated with SP600125 to test the stimulation of myogenesis.11 It was used to treat HepG2 cells to test the effects on oxysterol-i...


 Read more

Your Price
€111.80 10MG
€137.51 inc. VAT
REQUEST

Application

C2C12 myoblasts were treated with SP600125 to test the stimulation of myogenesis.11 It was used to treat HepG2 cells to test the effects on oxysterol-induced necrosis.12

Biochem/physiol Actions

A novel and selective inhibitor of c-Jun N-terminal kinase (JNK)

SP600125 is an anthrapyrazolone inhibitor of JNK that competes with ATP to inhibit the phosphorylation of c-Jun. It prevents the activation of inflammatory genes such as COX-2, IL-2 IFN-γ and TNF-α.8,9 It prevents the activation of JNK after brain ischemia and may be effective in treatment of ischemic stroke.10

assay≥98% (HPLC)
coloryellow
Gene Informationhuman ... JUN(3725), MAPK10(5602), MAPK9(5601)
InChI keyACPOUJIDANTYHO-UHFFFAOYSA-N
InChI1S/C14H8N2O/c17-14-9-5-2-1-4-8(9)13-12-10(14)6-3-7-11(12)15-16-13/h1-7H,(H,15,16)
Quality Level200
SMILES stringO=C1c2ccccc2-c3n[nH]c4cccc1c34
solubilityDMSO: 20 mg/ml, clear to very slightly hazy, faintly yellow to yellow, H2O: insoluble
storage temp.2-8°C
Cas Number129-56-6
This product has met the following criteria to qualify for the following awards:



PROCEED TO CHECKOUT

HAVE AN ACCOUNT? LOGIN
GUEST CHECKOUT

Proceed as a guest. You will have the option to register to access exclusive pricing and stock availability features after checkout.