Application

Reversine has been used as a monopolar spindle 1 (Mps1) kinase inhibitor or mitotic spindle assembly checkpoint (SAC) inhibitor:to study the need of mitotic arrest for combretastatin A4 (CA4)-mediated cytotoxicityto study the contribution of SAC activation to epstein-barr virus (EBV) replicationto induce chromosome mis-segregation

Biochem/physiol Actions

Reversine was first described as a synthetic substituted purine with activity as a dedifferentiation agent; it was shown to induces differentiated lineage-committed cells to become multipotent mesenchymal stem cells (MSCs). Reversine has also been show to have activity as a potent, selective human A₃ adenosine receptor antagonist (K_i value of 0.66 µM), as an ATP-competitive Aurora kinase inhibitor, and as a Mps1 kinase inhibitor. Additionally, studies have shown reversine to be an anti-cancer agent, inhibiting growth and inducing cell death in various cancer cell types.

Packaging

1, 5 mg in glass bottle