Application

Voriconazole has been used:as a control and Erg11 inhibitor in YPD mediumas a reference drug to test the activity of essential oils against clinical strains of Candida sp.as an antifungal agent to test its interactions with valproic acid (VPA)to compare its in vitro antifungal activity with essential oils and its components against Cryptococcus neoformans azole-susceptible and not-susceptible clinical isolates

Biochem/physiol Actions

Voriconazole is an antifungal used to treat serious fungal infections. Voriconazole inhibits ergosterol synthesis by inhibiting CYP450-dependent 14-α sterol demethylase resulting in a depletion of ergosterol in fungal cell membranes.

Voriconazole is used to treat invasive aspergillosis (IA). It is vigorous against Candidaspecies, includingthe strains ofCandida albicans, which shows resistance to fluconazole.

General description

Voriconazole is a triazole and a synthetic derivative of fluconazole.

Legal Information

Pfizer is a registered trademark of Pfizer, Inc.

Sold for research purposes under agreement from Pfizer Inc.

Other Notes

This compound was developed by Pfizer for Immunology research. To learn more about Sigma′s partnership with Pfizer and view other authentic, high-quality Pfizer compounds, visit sigma.com/bsm-pfizer.To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Packaging

5 mg in glass bottle

25 mg in poly bottle