NU7026, >=98% (HPLC), solid

Code: N1537-5MG D2-231

Application

Potent, ATP-competitive. IC50 = 0.23 µM. Selectivity over other PI3K-related kinases (IC50 = 13 µM for PI3K and >100 µM for A...


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€279.50 5MG
€343.79 inc. VAT
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Application

Potent, ATP-competitive. IC50 = 0.23 µM. Selectivity over other PI3K-related kinases (IC50 = 13 µM for PI3K and >100 µM for ATM and ATR).

NU7026 has been used:as a DNA-dependent protein kinase (DNA-PK) inhibitor, to pre-treat colon cancer cellin kinase inhibitor experiments for treating zygotes with visible pronuclei post 20 h-human chorionic gonadotropin (hCG)to determine its influence on cytotoxicity of dibenzo[def,p]chrysene on HepG2 cells

Biochem/physiol Actions

Cell permeable, small molecule benzochromenone inhibitor of DNA-PK (DNA dependent protein kinase).

Packaging

5 mg in glass bottle

assay≥98% (HPLC)
colortan
formsolid
InChI keyKKTZALUTXUZPSN-UHFFFAOYSA-N
InChI1S/C17H15NO3/c19-15-11-16(18-7-9-20-10-8-18)21-17-13-4-2-1-3-12(13)5-6-14(15)17/h1-6,11H,7-10H2
Quality Level100
shipped inwet ice
SMILES stringO=C1C=C(Oc2c1ccc3ccccc23)N4CCOCC4
solubilityDMSO: soluble 3 mg/mL at 60 °C, H2O: insoluble
storage temp.2-8°C
Cas Number154447-35-5
This product has met the following criteria to qualify for the following awards:



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