Nitazoxanide, >=98% (HPLC)

Code: N0290-10MG D2-231

Application

Nitazoxanide has been used: to test its anti-viral activity against chikungunya virusas an antiprotozoal agent to test its effect on cell viability in various can...


read more

Your Price
€86.13 10MG
€105.94 inc. VAT

Application

Nitazoxanide has been used: to test its anti-viral activity against chikungunya virusas an antiprotozoal agent to test its effect on cell viability in various cancer cell linesto test its effect on human cytomegalovirus (HCMV) infected human fibroblast HFF cells

Biochem/physiol Actions

Nitazoxanide is an inhibitor of pyruvate-ferredoxin oxidoreductase (PFOR); Antimicrobial recently found to kill both non-replicating and replicating mycobacteria. FDA approved anti-parasitic drug (2002). Recent work (C & EN Sept. 14, 2009, p. 28) highlights that NTZ kills non-replicating and replicating TB bacteria and no apparent resistance is detected.

Nitazoxanide (NTZ) promotes autophagy by acting on kinase based signaling pathways and acts on mammalian target of rapamycin complex 1 (mTORC1) in Mycobacteria. It has anti-viral property and effectively halts entry and release of chikungunya virus in in vitro studies. NTZ also inhibits Japanese encephalitis virus (JEV) infection in early stages and has the potential to treat other viral infections including dengue, hepatitis B (HBV), coronavirus and human immunodeficiency virus (HIV). It has antineoplastic functionality and may induce apoptosis by promoting proto-oncogene c-Myc inhibition resulting in tumor suppression.

Features and Benefits

This compound was developed by Romark. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

General description

Nitazoxanide (NTZ), a thiazolide compound is a antiparasitic drug with structure similar to niclosamide.

Packaging

10, 50 mg in glass bottle

assay≥98% (HPLC)
formpowder
InChI keyYQNQNVDNTFHQSW-UHFFFAOYSA-N
InChI1S/C12H9N3O5S/c1-7(16)20-9-5-3-2-4-8(9)11(17)14-12-13-6-10(21-12)15(18)19/h2-6H,1H3,(H,13,14,17)
originatorRomark
Quality Level100
SMILES stringCC(=O)Oc1ccccc1C(=O)Nc2ncc(s2)[N+]([O-])=O
storage temp.2-8°C
Cas Number55981-09-4
This product has met the following criteria to qualify for the following awards:



PROCEED TO CHECKOUT

HAVE AN ACCOUNT? LOGIN


GUEST CHECKOUT

Proceed as a guest. You will have the option to register to access exclusive pricing and stock availability features after checkout.