Application

2-Methoxyestradiol has been used: as hypoxia-inducible factor 1-alpha (HIF-1α) inhibitor to treat microglia to test whether hypoxia leads to cell deathto determine the anticancer potential in L-lactate-activated osteosarcoma cellsas a reference chemical and angiogenesis inhibitor to assess the performance of in vitroangiogenesis assay

Biochem/physiol Actions

2-Methoxyestradiolplays a key role in the apoptosis of tumor cells. It also participates in microtubule stabilization. It exhibits cardioprotective activity and acts as an anticancer agent.

2-Methoxyestradiol (2-ME) is a potent inhibitor of endothelial cell proliferation and angiogenesis.It has little affinity for classical estrogen receptors.

General description

2-Methoxyestradiol(2-ME) is a metabolite, derived from estradiol. It is usually seen at high levels in the normal follicle.

Other Notes

Tandem Mass Spectrometry data independently generated by Scripps Center for Metabolomics is available to view or download in PDF. M6383.pdf Tested metabolites are featured on Scripps Center for Metabolomics METLIN Metabolite Database. To learn more, visit sigma.com/metlin.

Packaging

5, 10, 50 mg in glass bottle