MJ33 lithium salt, powder, >=90% (NMR)

Application

MJ33 lithium salt has been used as a peroxiredoxin VI (Prdx6) inhibitor: to study its specific Prdx6 peroxidase activity in vitro and in breast cancer cell line (MCF-7) cell lysates to study its effects on a mouse model of acute lung injury associated with exposure to hyperoxiato study its potential use as a therapeutic agent

Biochem/physiol Actions

MJ33 acts as a non-toxic and potent inhibitor of agonist-induced activation of nicotinamide adenine dinucleotide phosphate (NADPH) oxidase type 2 (NOX2). It also prevents lung injuries associated with lung inflammation in mice. MJ33 is a fluorinated lipid analog, which blocks the enzyme by mimicking the transition state of the substrate.

Novel, active site directed, specific, competitive and reversible inhibitor of phospholipase A₂ (PLA₂).

Packaging

5 mg in glass bottle