LY-364947, >=98% (HPLC), solid

Code: L6293-5MG D2-231

Biochem/physiol Actions

LY-364947 is a selective, ATP-competitive inhibitor of Transforming Growth Factor-β Type I receptor kinase (TGF-β RI, ALK5) with IC...


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€226.80 5MG
€278.96 inc. VAT
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Biochem/physiol Actions

LY-364947 is a selective, ATP-competitive inhibitor of Transforming Growth Factor-β Type I receptor kinase (TGF-β RI, ALK5) with IC50 = 59 nM. It is much less potent at related kinases, with IC50 = 400 nM for TGF-β RII and IC50 = 1400 nM for mixed lineage kinase-7 (MLK-7), a kinase in the MAP kinase signal pathway and closely related to TGF-β RII. LY-364947 inhibits TGF-β-dependent cellular growth (IC50 = 81 nM) in NIH 3T3 mouse fibroblasts.

Packaging

5, 25 mg in glass bottle

assay≥98% (HPLC)
colorwhite to beige
formpowder
Gene Informationhuman ... TGFBR1(7046)
InChI keyIBCXZJCWDGCXQT-UHFFFAOYSA-N
InChI1S/C17H12N4/c1-2-6-15-13(5-1)12(8-10-19-15)14-11-20-21-17(14)16-7-3-4-9-18-16/h1-11H,(H,20,21)
Quality Level100
SMILES stringc1ccc(nc1)-c2n[nH]cc2-c3ccnc4ccccc34
solubilityDMSO: 2 mg/mL, clear
storage temp.2-8°C
Cas Number396129-53-6
Hazard Class6.1
Un Number2811
Pack GroupIII
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