beta-Lapachone, >=98% (TLC)

Application

β-Lapachone has been used:as an anticancer compound in catalase-inhibitable luminol/hydrogen peroxide (HRP)-dependent chemiluminometricassay in Lewis lung carcinoma (LLC) cells and isolated mitochondriaas a naphthoquinone to study its effects on the growth and differentiation of mice granulocyte and macrophage progenitor cellsas a substrate to study the enzyme activity of human recombinant NAD(P)H dehydrogenase 1 (NQO1) protein

Biochem/physiol Actions

β-Lapachone is a naturally occurring quinone obtained from the bark of the lapacho tree (Tabebuia avellanedae) with cancer chemopreventive properties. Induces apoptosis in HL-60 and human prostate cancer cells.

β-Lapachone acts as a DNA topoisomerase type I inhibitor. It exhibits anti-fungal, anti-bacterial, trypanocidal, and antiviral properties. β-Lapachone also inhibits nitric oxide(NO) and inducible NO synthase (iNOS) in alveolar macrophages.