Imidazolo-oxindole PKR inhibitor C16, >=98% (HPLC)

Code: I9785-5MG D2-231

Application

Imidazolo-oxindole PKR inhibitor C16 has been used:to rescue fear memory deficits and restore long-term potentiation (LTP) impairment in miceto inhibit the strong...


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€117.00 5MG
€143.91 inc. VAT
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Application

Imidazolo-oxindole PKR inhibitor C16 has been used:to rescue fear memory deficits and restore long-term potentiation (LTP) impairment in miceto inhibit the strong induction of interferon stimulated genes (ISGs) after plasmid transfection in HeLa-S3 cellsto augment eukaryotic translation initiation factor 2 (eIF2) activity

Biochem/physiol Actions

Imidazolo-oxindole PKR inhibitor C16 is a selective inhibitor of RNA-dependent protein kinases (PKR, Eif2ak2). C16 is a first reported, potent and selective PKR inhibitor. Its inhibition effect on PKR is ATP-binding site directed. C16 specifically inhibits the apoptotic PKR/eIF2a signaling pathway without stimulating the proliferative mTOR/p70S6K signaling mechanism.

C16 exhibits a neuroprotective role in adult brain injuries.

Packaging

5, 25 mg in glass bottle

assay≥98% (HPLC)
coloryellow to orange-brown
InChI keyVFBGXTUGODTSPK-BAQGIRSFSA-N
InChI1S/C13H8N4OS/c18-13-8(3-7-4-14-5-15-7)11-9(17-13)1-2-10-12(11)19-6-16-10/h1-6H,(H,14,15)(H,17,18)/b8-3-
Quality Level100
shipped inwet ice
SMILES stringO=C1NC2=CC=C3C(SC=N3)=C2/C1=C/C4=CNC=N4
solubilityDMSO: 12 mg/mL
storage temp.−20°C
Cas Number608512-97-6
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