8-Hydroxy-2-deoxyguanosine, >=98% (TLC)

Application

8-Hydroxy-2′-deoxyguanosine has been used:as a standard to analyse the oxidative DNA damage in the placenta of normal and abnormal pregnancies by electrochemical detectionas a standard for high performance liquid chromatography (HPLC) with electrochemical detection (ECD) measurementas a standard for HPLC and as a urinary marker of oxidative stress in order to assess the potentialantioxidantactivity of green coffee bean extract (GCBE) in vivoas a standard for LC/MS/MS analysis

Biochem/physiol Actions

A marker compound typically indicative of DNA damage associated with mutagenesis and carcinogenesis

The levels of 8-hydroxy-2′-deoxyguanosine helps in evaluating oxidative stress and DNA damage in individuals suffering from laryngeal cancer. Hence it serves as a major biomarker of DNA damage, induced by reactive oxygen species (ROS).

Packaging

1, 5 mg in glass bottle