G5172-5MG Display Image

GW4064, >=98% (HPLC)

Code: G5172-5MG D2-231

Application

GW4064 has been used:to investigate its ability to protect the livers of mice from lipopolysaccharide (LPS)-induced inflammation and apoptosisto examine its capab...


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Your Price
€163.57 5MG

Application

GW4064 has been used:to investigate its ability to protect the livers of mice from lipopolysaccharide (LPS)-induced inflammation and apoptosisto examine its capability to inhibit mucosal injury in ileum caused by lipopolysaccharide (LPS)to treat ileal explants

Biochem/physiol Actions

GW4064 is a FXR agonist. GW4064 is a potent (EC50 = 15 nM), non-steroidal agonist of the orphan nuclear receptor FXR. It shows no activity on other nuclear receptors including RAR up to 1 mM. This is an important tool for the study of the involvment of FXR in a variety of biological activities.

Features and Benefits

This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

General description

GW4064 is a synthetic isoxazole, which is used to decipher the cellular and physiological functions of farnesoid X receptor (FXR). It is an estrogen receptor-related receptors (ERRs) agonist.

Packaging

5, 25 mg in glass bottle

assay≥97% (HPLC)
colorwhite
formpowder
InChI keyBYTNEISLBIENSA-MDZDMXLPSA-N
InChI1S/C28H22Cl3NO4/c1-16(2)27-21(26(32-36-27)25-22(29)7-4-8-23(25)30)15-35-20-12-11-18(24(31)14-20)10-9-17-5-3-6-19(13-17)28(33)34/h3-14,16H,15H2,1-2H3,(H,33,34)/b10-9+
Quality Level100
SMILES stringCC(C)c1onc(c1COc2ccc(C=Cc3cccc(c3)C(O)=O)c(Cl)c2)-c4c(Cl)cccc4Cl
solubilityDMSO: 10 mg/mL, clear
storage conditiondesiccated
storage temp.2-8°C
Cas Number278779-30-9
This product has met the following criteria: