Geldanamycin from Streptomyces hygroscopicus, >=98% (HPLC), powder

Code: G3381-1MG D2-231

Biochem/physiol Actions

Geldanamycin is a potent antitumor antibiotic active at nanomolar concentration against 60 cell lines.Geldanamycin binds specifically to the heat shoc...


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€629.40 1MG
€774.16 inc. VAT
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Biochem/physiol Actions

Geldanamycin is a potent antitumor antibiotic active at nanomolar concentration against 60 cell lines.Geldanamycin binds specifically to the heat shock protein Hsp90 and to its endoplasmic reticulum homologue GP96, and thus interferes with conformational maturation of proteins and the cellular stress response. In addition, Geldanamycin is a potent inhibitor of the nuclear hormone receptor family.

Features and Benefits

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General description

Chemical structure: benzenoid

Packaging

1 mg in glass bottle

antibiotic activity spectrumneoplastics
assay≥98% (HPLC)
coloryellow to orange
formpowder
InChI keyQTQAWLPCGQOSGP-KSRBKZBZSA-N
InChI1S/C29H40N2O9/c1-15-11-19-25(34)20(14-21(32)27(19)39-7)31-28(35)16(2)9-8-10-22(37-5)26(40-29(30)36)18(4)13-17(3)24(33)23(12-15)38-6/h8-10,13-15,17,22-24,26,33H,11-12H2,1-7H3,(H2,30,36)(H,31,35)/b10-8-,16-9+,18-13+/t15-,17+,22+,23+,24-,26+/m1/s1
mode of actionenzyme | inhibits
Quality Level300
SMILES stringCO[C@H]1C[C@H](C)CC2=C(OC)C(=O)C=C(NC(=O)C(C)=CC=C[C@H](OC)[C@@H](OC(N)=O)C(C)=C[C@H](C)[C@H]1O)C2=O
solubilityDMSO: soluble
sterilitynon-sterile
storage temp.−20°C
Cas Number30562-34-6
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