Application

Furosemide has been used:to investigate the influence of timing of dexamethasone administration on auditory hair cell survival in miceto study its effect on intracranial pressure (ICP) after subcutaneous administration in ratsas a stimulant for renin release and subsequent increase in plasma angiotensin II (ANG II)

Biochem/physiol Actions

High ceiling

Furosemidecan block the Na⁺/K⁺/2Cl^-co-transporter in the ascending thick loop of Henle.It can enhance the synthesis of intrarenal prostaglandin. It enhances its ototoxicity in animals when used along with kanamycin. Furosemideis linked withthiamine insufficiency in individuals with heart failure.

Inhibits ion co-transport in the kidney.

Features and Benefits

This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound was developed by Sanofi Aventis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

General description

Furosemideis a an ototoxic high-ceiling diuretic.

Packaging

1, 5, 10, 25 g in glass bottle