Amsacrine hydrochloride, >=98% (TLC), powder

Application

Amsacrine hydrochloride has been used: as a topoisomerase poison in bacteriophage T4 topoisomerase assayas a topoisomerase inhibitor in Drosophila cell line, Kc167 as an antileukemia drug to test its effect on p53 transcriptional activity in tumor xenograftsas a topoisomerase II poison in dose-response assays in C elegans

Biochem/physiol Actions

Amsacrine hydrochloride is a DNA topoisomerase II inhibitor.

Amsacrine (m-AMSA) is a derivative of acridine and an antileukemia drug. It is an anticancer drug with antineoplastic activity that targets topoisomerase II. AMSA is an apoptosis inducer and favors the accumulation of double-stranded breaks (DSBs). It also inhibits the expression of matrix metallopeptidase 2 (MMP-2) and MMP-9 expression in leukemia cells by generating reactive oxygen species (ROS). AMSA serves as an adjuvant in trabeculectomy surgery.

Packaging

10, 50 mg in poly bottle