Anisomycin from Streptomyces griseolus, >=98% (HPLC), solid

Code: A9789-5MG D2-231

Biochem/physiol Actions

Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryot...


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€82.91 5MG
€101.98 inc. VAT

Biochem/physiol Actions

Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. Reported to induce apoptosis in a variety of cells including promyelocytic leukemia cells, Jurkat cells, ventricular myocytes, and colon adenocarcinoma cells. Initiates intracellular signals and immediate early gene induction. Selective signaling agonist. Potent Jun-NH2 terminal kinase (JNK) agonist. Activates mitogen-activated protein (MAP) kinases (JNK/SAPK and p38/RK). Antiprotozoal agent.

Caution

Hygroscopic

Packaging

5, 25, 100 mg in glass bottle

antibiotic activity spectrumneoplastics
assay≥98% (HPLC)
colorwhite to faint yellow
formsolid
InChI keyYKJYKKNCCRKFSL-RDBSUJKOSA-N
InChI1S/C14H19NO4/c1-9(16)19-14-12(15-8-13(14)17)7-10-3-5-11(18-2)6-4-10/h3-6,12-15,17H,7-8H2,1-2H3/t12-,13+,14+/m1/s1
mode of actionprotein synthesis | interferes
Quality Level300
SMILES stringCOc1ccc(C[C@H]2NC[C@H](O)[C@H]2OC(C)=O)cc1
solubilitymethanol: 20 mg/mL, DMSO: 20 mg/mL, H2O: 2 mg/mL (Aqueous solutions are stable over a wide range of pH at room temperature.)
storage temp.2-8°C
Cas Number22862-76-6
Hazard Class6.1
Un Number3462
Pack GroupIII
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