Application

Aconitine is a neurotoxin which activates tetrodotoxin-sensitive Na⁺ channels, inducing presynaptic depolarization and blocking the release of neurotransmitters. Aconitine also blocks norepinephrine reuptake. In the heart, aconitine induces ventricular tachycardia after intracoronary injection.

Aconitine has been used:to study its cardiotoxic effects along the pericardium meridian (PM) on cardiac rhythm in rabbitsas a standard in high-performance thin layer chromatography (HPTLC) fingerprinting methodin the aconitine-based lipo-alkaloids semi-synthesis

Biochem/physiol Actions

Neurotoxin. Activates tetrodotoxin-sensitive Na⁺ channels, inducing presynaptic depolarization, thus blocking the nerve action potential which, in turn, blocks the release of neurotransmitters and decreases the end plate potential at the neuromuscular junction. Aconitine also blocks norepinephrine reuptake. In the heart, aconitine induces ventricular tachycardia after intracoronary injection. In cultured ventricular myocytes, aconitine increases the duration of the action potential and induces the appearance of early after depolarization.

Aconitine is a diesterditerpenealkaloid found abundantly in the plant Aconitum genera. It possesses analgesic, antipyretic and antirheumaticactivity. Aconitine is involved in blocking neurotransmission. It acts as a neurotoxin as well as a cardiotoxin. Aconitine triggers ventricular tachycardia (VT) and ventricular fibrillation (VF). It interacts with voltage-dependent Na⁺ channels which results in the depolarization of membranes. Aconitine may exhibit therapeutic effects against systemic lupus erythematosus(SLE). It also inhibits the reuptake of norepinephrine.

Packaging

5, 25, 100, 250 mg in glass bottle