Calpain Inhibitor I, >=97% (TLC), powder

Code: A6185-5MG D2-231

Application

Calpain Inhibitor I have been used:as a component of protease inhibitor cocktail for gel shift analysisfor treating HeLa cell culturesfor inhibition of 26 S prote...


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€129.40 5MG
€159.16 inc. VAT
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Application

Calpain Inhibitor I have been used:as a component of protease inhibitor cocktail for gel shift analysisfor treating HeLa cell culturesfor inhibition of 26 S proteasome in 26 S proteasome inhibition assays

Biochem/physiol Actions

Calpain Inhibitor I inhibits tumor necrosis factor-induced (TNF-induced) cleavage of Poly (ADP-ribose) polymerase (PARP) and calpastatin in apoptosis. It also inhibits oxygen/glucose deprivation (OGD) induced cleavage of caspase-12 and Bcl-xL..

Can initiate apoptosis in HL-60 cells but blocks dexamethasone-induced apoptosis in thymocytes and cycloheximide-induced apoptosis in metamyelocytes. Inhibits cyclin B degradation and arrests the cell cycle at G1/S and at meta-/anaphase. Blocks induction of nitric oxide synthase by LPS in macrophages.

Packaging

5, 25 mg in serum bottle

assay≥97% (TLC)
biological sourcesynthetic (organic)
colorwhite
formpowder
Gene Informationhuman ... CAPN1(823), CTSB(1508), PSMA1(5682)
InChI keyFMYKJLXRRQTBOR-BZSNNMDCSA-N
InChI1S/C20H37N3O4/c1-7-8-9-16(12-24)22-19(26)18(11-14(4)5)23-20(27)17(10-13(2)3)21-15(6)25/h12-14,16-18H,7-11H2,1-6H3,(H,21,25)(H,22,26)(H,23,27)/t16-,17-,18-/m0/s1
Quality Level200
SMILES string[H]C(=O)[C@H](CCCC)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(C)=O
solubilityethanol: soluble, DMSO: soluble
storage temp.−20°C
Cas Number110044-82-1
This product has met the following criteria to qualify for the following awards:



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