Ascomycin from Streptomyces hygroscopicus var. ascomyceticus,

Code: A3835-1MG D2-231

Biochem/physiol Actions

Ascomycin is a strong immunosuppressant. It inhibits allogenic T-lymphocyte proliferation and can bind with high affinity to FKBP and inhibits calcine...


 Read more

Your Price
€243.27 1MG
€299.22 inc. VAT
REQUEST

Biochem/physiol Actions

Ascomycin is a strong immunosuppressant. It inhibits allogenic T-lymphocyte proliferation and can bind with high affinity to FKBP and inhibits calcineurin phosphatase in the nM range.

Ascomycin(FK520) possesses high anti-fungal and immunosuppressant activity. Ascomycin has been shown to inhibit the peptidyl-prolyl cis-trans isomerase activity of FK-506-binding proteins of T cells.

General description

Chemical structure: macrolactam

Ascomycin(FK520) is a macrolide and macrolactone antibiotic isolated from the soil bacterium, Streptomyces hygroscopicus var. ascomyceticus. Ascomycin is a C21 ethyl analog of the macrolide tacrolimus (FK-506). It is a 23-membered polyketide macrolide.

Linkage

An FK506 analog with an ethyl rather than an allyl group at position 21.

Packaging

1 mg in glass bottle

antibiotic activity spectrumfungi
formpowder
greener alternative categoryRe-engineered
greener alternative product characteristicsWaste PreventionAtom EconomyLess Hazardous Chemical SynthesesLearn more about the Principles of Green Chemistry.
greener alternative product scoreold score: 42new score: 10Find out more about DOZN™ Scoring
InChI keyZDQSOHOQTUFQEM-NURRSENYSA-N
InChI1S/C43H69NO12/c1-10-30-18-24(2)17-25(3)19-36(53-8)39-37(54-9)21-27(5)43(51,56-39)40(48)41(49)44-16-12-11-13-31(44)42(50)55-38(28(6)33(46)23-34(30)47)26(4)20-29-14-15-32(45)35(22-29)52-7/h18,20,25,27-33,35-39,45-46,51H,10-17,19,21-23H2,1-9H3/b24-18+,26-20+/t25-,27+,28+,29-,30+,31-,32+,33-,35+,36-,37-,38+,39+,43+/m0/s1
mode of actionenzyme | inhibits
Quality Level200
SMILES stringCCC1C=C(C)C[C@H](C)C[C@H](OC)C2O[C@](O)([C@H](C)C[C@@H]2OC)C(=O)C(=O)N3CCCC[C@H]3C(=O)OC([C@H](C)[C@@H](O)CC1=O)C(C)=C[C@@H]4CC[C@@H](O)[C@@H](C4)OC
storage temp.−20°C
Cas Number104987-12-4
This product has met the following criteria to qualify for the following awards:



PROCEED TO CHECKOUT

HAVE AN ACCOUNT? LOGIN
GUEST CHECKOUT

Proceed as a guest. You will have the option to register to access exclusive pricing and stock availability features after checkout.