AH6809, >=98%, crystalline solid or supercooled liquid

Application

AH6809 has been used:as a prostaglandin E2receptor1 & 2 (EP1/2) antagonist to analyze its effects on cyclooxygenase-2 /prostaglandin E2 (COX-2/PGE2)signaling in the angiogenic feedback of endothelial cells to hypoxiaas an EP2 antagonist to study its effects on tumor angiogenesis in human prostate cancer cell linesas an EP2 antagonist to analyze its effects on overexpression of amyloid precursor protein (APP)

Biochem/physiol Actions

DP/EP prostanoid receptor antagonist; has the highest affinity for DP receptors, but also acts as a weak antagonist at murine EP₁ and EP₂ prostanoid receptors.

AH6809 plays a role in antagonizing the proliferation of non-small cell lung cancer cell lines.

Features and Benefits

This compound is featured on the Prostanoid Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Packaging

5 mg in glass bottle