Monoclonal Anti-CD28 antibody produced in mouse, low endotoxin, clone CD28.2, purified immunoglobulin, buffered aqueous solution

Application

The reagent is designed for Flow Cytometry analysis. Suggested working dilution for Flow Cytometry is 2-8 µg/mL of sample. Indicated dilution is recommended starting point for use of this product. Working concentrations should be determined by the investigator.

Biochem/physiol Actions

Cluster of differentiation 28 (CD28) antigen has a role in T-cell activation, proliferation, survival and function. It modulates thymic development, peripheral homeostasis and the suppressive functions of regulatory T cells. CD28 has a role in signal transduction and is involved in activating many adaptor proteins. Mutation in the gene increases the risk of susceptibility to rheumatoid arthritis.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

General description

Cluster of differentiation 28 (CD28) antigen is a co-stimulatory receptor expressed in naive T-cells.[52} It contains a short cytoplasmic tail and two proline-rich motifs. CD28 is encoded by the gene mapped to human chromosome 2q33.2.

Immunogen

DC28.1.3.3 hybridoma cells

Physical form

Solution in azide free phosphate buffered saline, pH 7.4; 0.2 um filter sterilized. Endotoxin level is less than 10 EU/mg of the protein, as determined by the LAL test.