Application

Anti-Synaptophysin antibody produced in rabbit has been used in:immunocytochemistrywestern blottingimmunohistochemistry

Anti-synaptophysin antibody is suitable for use in immunohistochemistry and western blot.

Biochem/physiol Actions

Synaptophysin (SYP) modulates neurotransmitter release and synaptic plasticity. It maintains biogenesis and recycling of synaptic vesicles. SYP functions as a marker for neuroendocrine tumors. It is used as a potent marker for neuroendocrine prostate cancer (NEPC). Mutations in this gene is associated with X-linked intellectual disability.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Features and Benefits

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General description

Synaptophysin (SYP) is an integral membrane protein of synaptic vesicles. It is expressed in cortical synaptic terminals, during neurogenesis. The gene is located on human chromosome Xp11.23.

Synaptophysin is an integral membrane glycoprotein that is localized in presynaptic vesicles of nerve cells. This protein may regulate exocytosis and the formation of synaptic vesicles . Synaptophysin is encoded by the SYP gene and genetic alterations in SYP can lead to mental retardation . Anti-synaptophysin antibody specifically detects endogenous levels of total synaptophysin protein.

Immunogen

The antiserum was produced against synthesized peptide derived from human Synaptophysin.Immunogen Range: 101-150

Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.