Application

Anti-Lamin A antibody produced in rabbit has been used in immunoblotting.

Biochem/physiol Actions

Lamin A/C (LMNA) is involved in the structural organization of the nucleus. It modulates gene expression. It may play a role in osteoblastogenesis. Mutation in the LMNA gene is associated with muscle dystrophies, cardiomyopathies, lipodystrophies, and neuropathies. LMNA protein plays a vital role in cell cycle progression. It controls extracellular signal-regulated kinase (ERK)/mitogen-activated protein kinase (MAPK) and Wnt β-catenin pathway.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Features and Benefits

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General description

Lamin A/C (LMNA) gene codes for lamin A and C. Lamin A/C is a nuclear intermediate filament protein. LMNA gene is mapped to human chromosome 1q22. Anti-Lamin A Antibody detects endogenous levels of total Lamin A protein.

Immunogen

The antiserum was produced against synthesized peptide derived from human Lamin A/C.Immunogen Range: 361-410

Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.