Anti-DCT antibody produced in rabbit, approx. 1 mg/mL, affinity isolated antibody, buffered aqueous solution

Biochem/physiol Actions

Dopachrome tautomerase (DCT) participates in the production of melanin in melanosomes and also in the detoxification of the melanin precursors. It restricts the destructions induced by chemotherapeutic agents like X-ray or UVB (ultraviolet B) and gamma irradiation in melanoma cells and reduces the susceptibility of cell to oxidative stress.

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General description

Anti-DCT Antibody detects endogenous levels of total DCT protein.

Dopachrome tautomerase (DCT) is also termed as tyrosinase-related protein 2 (TYRP2). It is present in melanocytes, RPE (retinal pigment epithelium) cells and HaCaTs (basal keratinocytes). It is located on human chromosome 13q32.

Immunogen

The antiserum was produced against synthesized peptide derived from human DCT.Immunogen Range: 51-100

Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.