ANTI-PHOSPHO-CALMODULIN (PTHR79/SER81)

Biochem/physiol Actions

Calmodulin (CaM) encoded by Calmodulin 3 (CALM3) senses Ca₂⁺ and binds to free signal-transducing protein that regulates Cav1.2 L-type calcium channel and deactivates Cav1.2 when CaM binds to free Ca₂⁺. A sporadic mutation in CALM3 might be the cause for long QT syndrome, a disorder of ventricular myocardial repolarization, characterized by prolonged heart rate. CALM3 expression is higher in teratoma cells. CALM3 is a potential biomarker to dysregulate the melanoma cancer genes. Polymorphism in CALM3 is a potential modifier gene for familial hypertrophic cardiomyopathy.

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General description

Calmodulin 3 (CALM3) encodes calmodulin (CaM) protein 3 which is expressed five folds more than CALM1 and CALM2. CALM3 promoter has high GC content and no TATA box like that of housekeeping gene. CALM3 contains several pro-alpha1 (AP1) and pro-alpha2 (AP2) consensus sites and several CAAT regions. CALM3 also has clusters of specificity protein 1 (SP1) transcription factor. In human chromosome, the gene is localized on 19q13.32.

Immunogen

Peptide sequence around phosphorylation site of threonine79/serine81(K-D-T(p)-D-S(p)-E-E) derived from Human Calmodulin .

Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Specificity

The antibody detects endogenous level of Calmodulin only when phosphorylated at threonine 79/serine 81.