SAB4200816-100UL Display Image

ANTI-CALCINEURIN (ALPHA-SUBUNIT) ANTIBO

Code: SAB4200816-100UL D2-231

Application

The antibody may be used in various immunochemical techniques including Immunoblot1,2 (~61 kDa), ELISA and Immunohistochemistry1,3.

Disclaimer

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€406.00 EACH
€499.38 inc. VAT

Application

The antibody may be used in various immunochemical techniques including Immunoblot1,2 (~61 kDa), ELISA and Immunohistochemistry1,3.

Disclaimer

Unless otherwise stated in our catalog our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

General description

Calcineurin (a-subunit) (CnA), also known as Serine/threonine-protein phosphatase 2B catalytic subunit alpha (PP3CA), Calmodulin-dependent calcineurin A subunit alpha (CALN/CALNA) or CAM-PRP catalytic subunit, is a major soluble calmodulin-binding protein in the brain. Calcineurin is a heterodimer metalloenzyme, Ca2+/Calmodulin dependent serine/threonine protein phosphatase 3 (PPP3), with a relatively narrow substrate specificity4-6,8 It is composed of two subunits, a catalytic calmodulin-binding a subunit (61 kDa, calcineurin A [CnA]) and regulatory calcium-binding ß subunit (18 kDa, calcineurin B [CnB]).6,7 Both subunits are highly conserved from yeast to mammals.8

Immunogen

Purified bovine brain calcineurin.

Physical form

Supplied as a solution in 0.01 M phosphate buffered saline pH 7.4, containing 15 mM sodium azide as a preservative.

Specificity

Monoclonal Anti-Calcineurin specifically recognizes an epitope located on the a-subunit of calcineurin from human, mouse, monkey, porcine1, rat2 and bovine13 origin. It does not cross-react with calcineurin ß-subunit.

Storage and Stability

For extended storage, freeze in working aliquots. Repeated freezing and thawing is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilution samples should be discarded if not used within 12 hours.

antibody formpurified from hybridoma cell culture
antibody product typeprimary antibodies
biological sourcemouse
cloneCN-A1, monoclonal
concentration~1 mg/mL
Gene Informationbovine ... PPP3CA(286852)human ... CALNA(5530)rat ... Caln1(363909)
isotypeIgG1
packagingantibody small pack of 25 µL
shipped indry ice
species reactivityhuman, bovine, rat
storage temp.−20°C
technique(s)immunoblotting: 1.25-2.5 µg/mL using mouse or rat brain tissue extract.
UniProt accession no.Q08209
Code
Description
Unit Size
List Price
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SAB4200816-25UL
Unit:EACH
List Price: €152.00
Source:List Price
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