ANTI-ACE2

Biochem/physiol Actions

Angiotensin-converting enzyme-2 (ACE2) as a carboxypeptidase cleaves angiotensin (Ang) I to Ang 1-9. In addition, it also degrades Ang II to Ang 1–7 and plays a vital role in regulation of blood pressure. Ace 2 aids in maintaining the balance of local renin-angiotensin system (RAS). It also helps in absorbing the neutral amino acids from the intestine and the kidney. It is a cellular receptor for spike glycoprotein of severe acute respiratory syndrome-coronavirus (SARS-CoV) and the new coronavirus (SARS-CoV-2), which is known to cause coronavirus disease 2019 (COVID-19). Downregulated expression of Ace 2 has been observed in patients with cardiovascular diseases.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Features and Benefits

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General description

Angiotensin-converting enzyme-2 (ACE2), also referred as ACEH (human ACE homolog), is an integral membrane protein. It is encoded by the gene located at human chromosome Xp22.2. Ace 2 is found in variety of tissues, but the higher levels of protein is observed in vascular endothelium, lungs, heart, kidney, and testis. The protein contains a N-terminal single catalytic metallopeptidase unit, a C-terminal noncatalytic domain and a cytoplasmic tail.

Immunogen

Antibody was raised against a synthetic peptide corresponding to amino acids near the C-terminus of human ACE2.

Linkage

The action of this antibody can be blocked using blocking peptide SBP3500977.

Physical form

Supplied at 1 mg/mL in PBS with 0.02% sodim azide.