ANTI-BAT1(C-TERMINAL)

Application

ANTI-BAT1(C-TERMINAL) antibody produced in rabbit has been used in immunoprecipitation and western blotting.

Biochem/physiol Actions

BAT1/ UAP56 facilitates the binding of U2 small nuclear ribonucleoprotein (SnRP) to pre-mRNA. It also helps in the export of mRNA from the nucleus to the cytoplasm. Spliceosome RNA helicase BAT1 is implicated in adapting nucleic acid metabolism to cellular stress. BAT1 is implicated in the down-regulation of inflammation. The gene polymorphism might be associated with the development of allergic diseases such as bronchial asthma, allergic rhinitis, atopic dermatitis, food allergy, drug allergy and pollen allergy. Mutation in the gene may also lead to the development of urticaria and Quincke’;s edema.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

General description

BAT1, also known as UAP56 or DExD-box helicase 39B (DDX39B), is encoded in the central region of the major histocompatibility complex (MHC) on the short arm of human chromosome 6p21.33. It is a member of DEAD box family of RNA-binding proteins and is characterized with the nine conserved motifs including ATPase and RNA helicase motifs.

Physical form

Supplied in PBS with 0.09% (W/V) sodium azide