ANTI-HIF1ALPHA(C-TERMINAL)

Biochem/physiol Actions

Hypoxia-inducible factor-1 (HIF1) plays an essential role in cellular and systemic homeostatic responses to hypoxia. During hypoxia, the two subunits of this factor undergo post-translational modifications, which in turn promote transactivation. Overexpression of a natural antisense transcript (aHIF) of this gene has been shown to be associated with nonpapillary renal carcinomas. HIF-1α is a master regulator of the hypoxic response, and its proangiogenic activities include, but are not limited to, regulation of vascular endothelial growth factor (VEGF).

Disclaimer

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General description

Hypoxia-inducible factor-1 (HIF1) is a transcription factor expressed in mammalian cells when cultured under reduced oxygen tension. HIF1 is a heterodimer composed of an α subunit and a β subunit. The β subunit has been identified as the aryl hydrocarbon receptor nuclear translocator (ARNT). This gene encodes the alpha subunit of HIF-1. HIF-1α contains two transactivation domains. The gene encoding it is localized on human chromosome 14q23.2.

Physical form

Supplied in PBS with 0.09% (W/V) sodium azide