Application

Research CategoryNeuroscience

Research Sub CategoryDevelopmental Signaling

Anti-SLC22A3 Antibody, clone 4H6.1, Cat. No. MABN359, is a highly specific mouse monoclonal antibody, that targets SLC22A3 and has been tested in Western Blotting.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

General description

Solute carrier family 22 member 3 (UniProt O75751; also known as EMT, Extraneuronal monoamine transporterorganic cation transporter 3, Organic cation transporter 3) is encoded by the SLC22A3 (also known as EMTH, OCT3) gene (Gene ID 6581) in human. Solute carrier family 22 member 3 is a multi-transmembrane protein that mediates the outward transport and clearance of endogenous small organic cations as well as a wide array of drugs and environmental toxins. Known substrates for this transporter include histamine, serotonin, norepinephrine, dopamine and MPP+.

Immunogen

GST-tagged recombinant protein corresponding to the C-terminal of human SLC22A3.

Epitope: C-terminal

Linkage

Replaces: MABN1039

Other Notes

Concentration: Please refer to lot specific datasheet.

Physical form

Purified mouse monoclonal IgG1κ antibody in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

Protein G Purified

Format: Purified

Quality

Evaluated by Western Blotting in human brain tissue lysate.

Western Blotting Analysis: 2.0 µg/mL of this antibody detected SLC22A3 in 10 µg of human brain tissue lysate.

Storage and Stability

Stable for 1 year at 2-8°C from date of receipt.

Target description

~70 kDa observed. Due to glycosylation, the target band appears larger than the calculated molecular weight of 61.3 kDa