AntiAngiotensinConvertingEnzyme;clone2E2

Analysis Note

ControlRat Angiotensin Converting Enzyme

Application

Anti-Angiotensin Converting Enzyme Antibody, clone 2E2.

General description

Angiotensin-converting enzyme (ACE) is a zinc-metallopeptidase belonging to the peptidase M2 family. It catalyzes the conversion of angiotensin I to angiotensin II and the degradation of bradykinin, which increases the vasoconstrictive effects of angiotensin. The Angiotensin-converting enzyme plays an important role in maintaining cardiac function and vascular tone. It is highly expressed in the heart, lung, kidney, gastrointestinal system, and prostate. Defects in the Angiotensin-converting may contribute cardiac disease; and renal tubular dysgenesis, a condition characterized by persistent fetal anuria and perinatal death.

Immunogen

Human Angiotensin Converting Enzyme.

Linkage

Replaces: MAB3502

Physical form

Mouse monoclonal IgG1 cultured supernatant without preservatives.

Quality

Evaluated by Western Blot in rat Angiotensin Converting Enzyme.

Western Blot Analysis: A 1:2,000 dilution of this antibody detected rat Angiotensin Converting Enzyme in WB.

Target description

~180 kDa observed. The calculated molecular weight is 150 kDa; however, this protein is known to be glycolsylated.