Application

Anti-MAP2 antibody is suitable for use in immunohistochemistry (1:500 using Zamboni’;s fixative-fixed, frozen mouse spinal cord and thalamus sections) , flow cytometry (1:200-1:500), immunoblotting (approx. 72 kDa and 280 kDa) and western blot (1:500-1:1,000).

Anti-MAP2 antibody produced in rabbit has been used in immunocytochemistry.

Biochem/physiol Actions

Microtubule associated protein 2 (MAP2) plays a critical role in the formation of dendritic protrusions in astrocytes and oligodendrocytes. It maintains the homeostasis of microtubules. The protein plays an important role in neuronal plasticity.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

General description

Microtubule associated protein 2 (MAP2) is a neuron specific protein, which is highly expressed in the central nervous system. It is the member of cytoskeletal proteins. The gene is located on human chromosome 2q34.

MAP2 is a microtubule-associated protein that regulates the structure and function of the cytoskeleton. The protein also modulates morphogenesis of neurons and cell proliferation. Interactions of MAP2 with F-actin have been implicated in neurite initiation and microtubular re-organization. Decreased levels of MAP2 have been associated with transmissible spongiform encephalopathies . Anti-MAP2 antibody is specific for MAP2 in human, mice and rats.

Immunogen

synthetic peptide corresponding to residues 2-15 of human MAP2.

Physical form

solution in phosphate buffered saline, containing 0.02% sodium azide.