ANTI-PNLDC1

Application

All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project and as a result, are supported by the most extensive characterization in the industry. The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. We also provide Prestige Antibodies^® protocols and other useful information.

Biochem/physiol Actions

PNLDC1 (PARN like, ribonuclease domain containing 1) is a Mg²⁺-dependent exonuclease. In silkworm (Bombyx mori), it is responsible for 3′ pre-piRNA trimming. In humans, PNLDC1 exhibits 3′-5′ exonuclease activity under in vitro conditions. This activity is specific for DNA or RNA polyadenylates. PNLDC1 might be involved in the maintenance of genome integrity and posttranscriptional regulation and checking. It might also be associated with affective psychosis.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Features and Benefits

Prestige Antibodies^® are highly characterized and extensively validated antibodies with the added benefit of all available characterization data for each target being accessible via the Human Protein Atlas portal linked just below the product name at the top of this page. The uniqueness and low cross-reactivity of the Prestige Antibodies^® to other proteins are due to a thorough selection of antigen regions, affinity purification, and stringent selection. Prestige antigen controls are available for every corresponding Prestige Antibody and can be found in the linkage section.Every Prestige Antibody is tested in the following ways: IHC tissue array of 44 normal human tissues and 20 of the most common cancer type tissues. Protein array of 364 human recombinant protein fragments.

General description

The gene PNLDC1 (PARN like, ribonuclease domain containing 1) is mapped to human chromosome 6q. It is a homologue of PARN (poly(A)-specific ribonuclease). The protein is present in the cytoplasm of stem and spermatogenic cells. The protein has a putative transmembrane domain. The PNLDC1 protein also contains an RNaseH-like domain and RNAse_CAF1 (CCR4-associated factor 1) domain. PNLDC1 is mainly expressed in the early stages of development and upon differentiation.

Immunogen

poly(A)-specific ribonuclease (PARN)-like domain containing 1 recombinant protein epitope signature tag (PrEST)

Legal Information

Prestige Antibodies is a registered trademark of Sigma-Aldrich Co. LLC

Linkage

Corresponding Antigen APREST85571.

Physical form

Solution in phosphate buffered saline, pH 7.2, containing 40% glycerol and 0.02% sodium azide.