Analysis Note

ControlHEK293 cells

Application

Research Sub CategoryNeurodegenerative Diseases

Milli-Mark Anti-PINK1-Alexa Fluor 488 Antibody, clone N4/49 is an antibody against PINK1-Alexa Fluor 488 for use in FC.

Research CategoryNeuroscience

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

General description

Mutations in the PTEN-induced kinase 1 (PINK1) gene located within the PARK6 locus on chromosome 1p35-p36 have recently been identified in patients with recessive early-onset Parkinson disease. Data suggests that PINK1 may be the second most common causative gene next to parkin in parkinsonism with the recessive mode of inheritance.

Immunogen

Recombinant protein corresponding to human PINK1.

Legal Information

ALEXA FLUOR is a registered trademark of Life Technologies

MILLI-MARK is a registered trademark of Merck KGaA, Darmstadt, Germany

Physical form

Protein G Purified

Purified mouse monoclonal IgG1k conjugated to Alexa Fluor^® 488 in PBS with 0.1% sodium azide and 15 mg/mL BSA.

Quality

Evaluated by flow cytometry using HEK293 cells.

Specificity

Antibody recognizes human PINK1.

Storage and Stability

Maintain refrigerated at 2-8 °C protected from light in undiluted aliquots for up to 6 months from date of receipt.

Target description

Uniprot describes two isoforms exist with calculated Mw of 63 and 30 kDa