Application

Anti-SLC1A4 polyclonal antibody is used to tag solute carrier family 1 (glutamate/neutral amino acid transporter), member 4 for detection and quantitation by Western blotting and in plasma by immunohistochemical (IHC) techniques. It is used as a probe to determine the roles of solute carrier family 1 (glutamate/neutral amino acid transporter), member 4 in the concentrative uptake of neutral amino acids such as alanine, glutamate, serine, cysteine and the imino acids, hydroxyproline and proline.

Biochem/physiol Actions

SLC1A4 is a transporter for alanine, serine, cysteine, and threonine. It exhibits sodium dependence.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

General description

Solute carrier family 1 (glutamate/neutral amino acid transporter), member 4 (ASCT1, SATT, SLC1A4) is a sodium dependent concentrative transporter of neutral amino acids such as alanine, glutamate, serine, cysteine and the imino acids, hydroxyproline and proline. Defective SLC1A4 has been linked to multiple system atrophy (MSA), an adult-onset sporadic neurodegenerative disease.

Immunogen

Synthetic peptide directed towards the C terminal region of human SLC1A4

Physical form

Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

Sequence

Synthetic peptide located within the following region: ATKKGEQELAEVKVEAIPNCKSEEETSPLVTHQNPAGPVASAPELESKES

Specificity

Anti-SLC1A4 polyclonal antibody reacts with bovine, human, mouse, rat, chicken, and zebrafish solute carrier family 1 (glutamate/neutral amino acid transporter), member 4 proteins.