Anti-Claudin-11

Analysis Note

ControlHuman brain tissue lysate

Application

Western Blot Analysis: 1 µg/mL from a representative lot detected Claudin-11 in human kidney tissue lysate.

Western Blot Analysis: 2 µg/mL from a representative lot detected Claudin-11 in human testis tissue lysate.

Research CategoryCell Structure

Anti-Claudin-11 Antibody is an antibody against Claudin-11 for use in Western Blotting.

Research Sub CategoryECM Proteins

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

General description

Claudin-11 (CLDN11; or Oligodendrocyte-specific protein) is expressed in Sertoli cells of the testis. It is involved in the formation of tight junctions, which is required for spermatogenesis. Previous studies have indicated that claudin-11 may prevent the progression of bladder cancer by blocking cell invasion and metastatis.

Immunogen

Epitope: Cytoplasmic domain

KLH-conjugated linear peptide corresponding to the cytoplasmic domain of human Claudin-11.

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Physical form

Affinity purified

Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

Quality

Evaluated by Western Blot in human brain tissue lysate.

Western Blot Analysis: 0.5 µg/mL of this antibody detected Claudin-11 in 10 µg of human brain tissue lysate.

Specificity

Other homologies: Mouse and Rat (93% sequence homology).

This antibody recognizes the cytoplasmic domain of Claudin-11.

Storage and Stability

Stable for 1 year at 2-8°C from date of receipt.

Target description

~22 kDa observed. An uncharacterized band may be observed at ~60 kDa in some tissue lysates.