Anti-FABP7

Application

This Anti-FABP7 Antibody is validated for use in Western Blotting_x000D_ and Immunohistochemistry for the detection of FABP7.

Research CategorySignaling

Research Sub CategoryDevelopmental Signaling

Immunohistochemistry Analysis (IHC): 5 µg/mL from a representative lot detected FABP7 in human breast tissue.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

General description

FABP7 is a member of the large family of hydrophobic ligand-binding proteins (FABPs). FABP proteins are involved in lipid metabolism, including uptake and intracellular trafficking of fatty acids and retinoids. In addition, they play a role in gene regulation, cell signaling, cell growth and differentiation. Several reports have suggested a possible role for the different FABP proteins in cancer biology, linking their levels with either increasing or decreasing the degree of malignancy. Nine FABPs (FABP1-FABP9) have been identified. FABP7 is a brain-specific protein that is required for the establishment of the radial glial fiber system in the developing brain, a system that is necessary for the migration of immature neurons to establish cortical layers. It is expressed at high levels in the developing central nervous system. FABP7 has also been found in melanocytic lesions and has shown to regulate proliferation and invasion in melanoma cells in vitro, suggesting that it may play a role in cell proliferation and invasion.

Immunogen

Epitope: Near Center

FABP7 antibody was raised against a 17 amino acid synthetic peptide from near the center of human FABP7.

Linkage

Replaces: MABS184

Other Notes

Concentration: Please refer to lot specific datasheet.

Physical form

Antigen Affinity Purified

Purified rabbit polyclonal in buffer containing PBS (pH 7.2) with 0.02% sodium azide.

Quality

Evaluated by Western Blotting in human breast tissue lysate.

Western Blotting Analysis (WB): 1 µg/mL of this antibody detected FABP7 in human breast tissue lysate.

Storage and Stability

Stable for 1 year at 2-8°C from date of receipt.

Target description

~24 kDa observed. Uncharacterized bands may be observed in some lysate(s).