Application

Research CategorySignaling

Research Sub CategoryMetabolic Hormones & Receptors

Western Blotting Analysis: 2.0 µg/mL from a representative lot detected RBP4 in 10 µg of human spleen, thymus, ovary and testis tissue lysates.

Anti-RBP4 Antibody is a highly specific rabbit polyclonal antibody, that targets Retinol binding protein 4 & has been tested in western blotting.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

General description

The role of the protein retinol binding protein 4 (RBP4) has always been understood to be involvement in the transport of vitamin A. However, research has demonstrated that blood levels of RBP4 is closely linked with the development of insulin resistance, which predisposes individuals to type 2 diabetes and is a major risk factor for cardiovascular disease. In addition higher levels of RBP4 were closely associated with other components of metabolic syndrome, including increased body mass index, waist-to-hip ratio, serum triglyceride levels and systolic blood pressure, as well as decreased HDL levels. Further investigations indicate that RBP4 may be a useful biomarker in identifying a predisposition to type 2 diabetes and measuring therapeutic improvement.

Immunogen

Recombinant protein corresponding to human RBP4.

Linkage

Replaces: MABN1095

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Physical form

Affinity purified

Purified rabbit polyclonal in buffer containing PBS with 0.05% sodium azide.

Quality

Evaluated by Western Blotting in human liver tissue lysate.

Western Blotting Analysis: 2.0 µg/mL of this antibody detected RBP4 in 10 µg of human liver tissue lysate.

Storage and Stability

Stable for 1 year at 2-8°C from date of receipt.

Target description

~23 kDa observed