Anti-PDE4D

Code: ABS22 D2-231

Application

Anti-PDE4D Antibody is an antibody against PDE4D for use in WB.

General description

Phosphodiesterase 4D (PDE4D) is a member of the P...


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Application

Anti-PDE4D Antibody is an antibody against PDE4D for use in WB.

General description

Phosphodiesterase 4D (PDE4D) is a member of the PDE cyclic nucleotides. PDE4D is known to be regulated by protein kinase C (PKC)-Raf-MEK-ERK and also by cAMP in vascular smooth muscle cells. PDE4D is essential to have equilibrium in relaxing and contracting cues to airway smooth muscle. Down-regulation of PDE4D may be associated with analgesic and anti-inflammatory effects. It has also been linked to the risk of stroke, specifically common polygenic stroke.

Immunogen

GST-tagged recombinant protein corresponding to the C-terminus of human PDE4D.

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Physical form

Format: Purified

Quality

Evaluated by Western Blot in rat brain tissue lysate.

Western Blot Analysis: 0.5 µg/mL of this antibody detected PDE4D on 10 µg of rat brain tissue lysate.

Specificity

This antibody recognizes PDE4D at the C-terminus.

Target description

~ 59, 68, 85, 90, and 105 kDa observed. UniProtKB/Swiss-Prot Q08499 (PDE4D_HUMAN) entry describes 12 isoforms produced by alternative splicing: Isoform 1 at 91.115 kDa, Isoform 2 at 76.369 kDa, Isoform 3 at 68.607 kDa, Isoform 4 at 66.376 kDa, Isoform 5 at 57.792 kDa, Isoform 6 at 84.428 kDa, Isoform 7 at 23.839 kDa, Isoform 8 at 59.113 kDa, Isoform 9 at 77.705 kDa, Isoform 10 at 76.816 kDa, Isoform 11 at 84.662 kDa, and Isoform 12 at 24.429 kDa

antibody formpurified antibody
biological sourcerabbit
clonepolyclonal
Gene Informationhuman ... PDE4D(5144)
NCBI accession no.NP_001098101
Quality Level100
shipped inwet ice
species reactivity (predicted by homology)mouse (based on 90% sequence homology), chimpanzee (based on 100% sequence homology)
species reactivityrat, human
technique(s)western blot: suitable
UniProt accession no.Q08499
This product has met the following criteria to qualify for the following awards:



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