Anti-Aquaporin-4

Analysis Note

ControlHuman brain tissue lysate

Application

Anti-Aquaporin-4 is an antibody targeting the Aquaporin-4 protein, validated for use in WB.

Research CategoryNeuroscience

Research Sub CategoryDevelopmental Neuroscience

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

General description

Aquaporin-4 (AQP-4) is also known as Mercurial-insensitive water channel. AQP-4 is an osmoreceptor which regulates body water balance and mediates water flow within the central nervous system. It is expressed predominantly in the mature brain, but also in the eye, kidney, intestine and lung. AQP-4 is a multi-pass membrane protein that is part of a complex along with MLC1, TRPV4, HEPACAM and ATP1B1.

Immunogen

KLH-conjugated linear peptide corresponding to the cytoplasmic domain of rat Aquaporin-4.

Epitope: Cytoplasmic domain

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Physical form

Affinity purified

Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

Quality

Evaluated by Western Blotting in human brain tissue lysate.

Western Blotting Analysis: 1.0 µg/mL of this antibody detected Aquaporin-4 in 10 µg of human brain tissue lysate.

Specificity

This antibody recognizes the cytoplasmic domain of Aquaporin-4.

Storage and Stability

Stable for 1 year at 2-8°C from date of receipt.

Target description

~32 kDa observed