Anti-NLRP6 (NALP6)

Code: ABF29 D2-231

Analysis Note

ControlRat basophilic leukemia (RBL) cell lysate

Application

Immunohistochemistry Analysis: A 1:1,000 dilution from a representativ...


 Read more

Your Price
€388.00 EACH
€477.24 inc. VAT

Analysis Note

ControlRat basophilic leukemia (RBL) cell lysate

Application

Immunohistochemistry Analysis: A 1:1,000 dilution from a representative lot detected NLRP6 (NALP6) in epithelial tissue of proximal and distal tubules of human kidney, and in human bone marrow tissue.

Anti-NLRP6 (NALP6) Antibody detects level of NLRP6 (NALP6) & has been published & validated for use in WB, IH(P).

General description

NRLP6 (NALP6) (also known as PYRIN-containing Apaf-1-like protein 5 or PYPAF5) belongs to a family of proteins that play a critical role in apoptosis and in inflammatory signaling. Its expression is highly restricted to granulocytes and T-cells. Co-expression of NALP6 with ASC results in synergistic activation of caspase-1-dependent cytokine processing, subsequent NF-kB activation, and downstream recruitment of PYPAF5 to punctate structures in the cytoplasm. Overlapping genes in NALP6/PYPAF5 locus encode two V2-type vasopressin isoreceptors: angiotensin-vasopressin receptor (AVR) and non-AVR.

Immunogen

Linear peptide corresponding to NACHT domain of human NLRP6 (NALP6).

Epitope: NACHT domain

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Quality

Evaluated by Western Blot in rat basophilic leukemia (RBL) cell lysate.

Western Blot Analysis: 1 µg/mL of this antibody detected NLRP6 (NALP6) in 10 µg of rat basophilic leukemia (RBL) cell lysate.

Specificity

This antibody recognizes the NACHT domain of NLRP6 (NALP6).

Other homologies: Mouse (93% sequence homology).

Target description

~99 kDa observed

antibody formaffinity isolated antibody
antibody product typeprimary antibodies
biological sourcerabbit
clonepolyclonal
Gene Informationhuman ... NLRP6(171389)
NCBI accession no.NP_612202
purified byaffinity chromatography
Quality Level100
shipped inwet ice
species reactivity (predicted by homology)rhesus macaque (based on 100% sequence homology)
species reactivityrat, human
technique(s)western blot: suitable, immunohistochemistry: suitable (paraffin)
UniProt accession no.P59044
This product has met the following criteria to qualify for the following awards:



HAVE AN ACCOUNT? LOGIN

GUEST CHECKOUT

Proceed as a guest. You will have the option to register to access exclusive pricing and stock availability features after checkout.