Application

Research CategoryEpigenetics & Nuclear Function

Anti-SIK1 Antibody detects level of SIK1 & has been published & validated for use in SIK1.

Research Sub CategoryCell Cycle, DNA Replication & Repair

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

General description

Salt-inducible kinase 1 (SIK1), also known as SNF1LK or MSK, plays a role in histone modification and G2/M cell cycle regulation. It is a 783 amino acid protein that contains one UBA domain and belongs to the Ser/Thr protein kinase family (AMPK subfamily). Localized to both the nucleus and the cytoplasm, SIK1 is a class II HDAC kinase that uses magnesium as a cofactor to catalyze the ATP-dependent phosphorylation of target proteins and is thought to be important for the early stages of skeletal muscle growth and myocardial cell differentiation.

Immunogen

KLH-conjugated synthetic peptide corresponding to the center region of human SIK1.

Epitope: center region

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Physical form

Antigen Affinity Purified

Purified rabbit polyclonal in buffer containing PBS with up to 0.1% sodium azide.

Quality

Evaluated by Western Blotting in human small intestine tissue lysate.

Western Blotting Analysis: 1 µg/mL of this antibody detected SIK1 in human small intestine tissue lysate.

Storage and Stability

Stable for 1 year at 2-8°C from date of receipt.

Target description

~82 kDa observed. Uncharacterized bands may be observed in some lysate(s).