Anti-ZIP-1

Application

Anti-ZIP-1 Antibody detects level of ZIP-1 & has been published & validated for use in ZIP-1.

Research CategoryApoptosis & Cancer

Immunohistochemistry Analysis: 2.5 µg/mL from a representative lot detected ZIP-1 in human kidney tissue.

Research Sub CategoryApoptosis - Additional

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

General description

Zinc transporter ZIP1, also known as Solute carrier family 39 member 1 or Zinc-iron-regulated transporter-like or Zrt- and Irt-like protein 1 (ZIP-1 or hZIP1), and encoded by the gene name SLC39A1 or IRT1 or ZIP1 or ZIRTL, is responsible to the rapis uptake and accumulation of physiologically effective zinc in prostate cells. Zinc is an essential ion for cells and plays significant roles in the growth, development, and differentiation. ZIP1 expression is markedly downregulated in a number of cancerous tissues and is thought to function as a tumor suppressor gene in prostate cancer. More recent studies have shown that overexpression of ZIP1 and concomitant increased levels of intracellular zinc in PC-3 cells cause a significant inhibition of NF-κB, leading to downregulation of the antiapoptotic protein Bcl-2, Bcl-XL, and the apoptosis inhibitor XIAP, reducing the malignant potential of prostate cancer cells in vitro and in vivo.

Immunogen

KLH-conjugated synthetic peptide corresponding to the N-terminus of human ZIP-1.

Epitope: N-terminus

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Physical form

Antigen Affinity Purified

Purified rabbit polyclonal in buffer containing PBS with up to 0.1% sodium azide.

Quality

Evaluated by Western Blotting in Mouse kidney tissue lysate.

Western Blotting Analysis: 2 µg/mL of this antibody detected ZIP-1 in Mouse kidney tissue lysate.

Specificity

This antibody is predicted to not cross-react with other ZIP family members.

Storage and Stability

Stable for 1 year at 2-8°C from date of receipt.

Target description

~40 kDa observed. Uncharacterized bands may be observed in some lysate(s).